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Article

Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs.

mBio - 6 Jun 2017

Harding Alfred T, Heaton Brook E, Dumm Rebekah E, Heaton Nicholas S

Abstract excerpt

Influenza virus vaccine production is currently limited by the ability to grow circulating human strains in chicken eggs or in cell culture. To facilitate cost-effective growth, vaccine strains are serially passaged under production conditions, which frequently results in mutations of the major antigenic protein, the viral hemagglutinin (HA). Human vaccination with an antigenically drifted strain is known to...

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Source

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Identifiers

PMID: 28588131
DOI: 10.1128/mBio.00669-17
PMCID: PMC5461409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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