Article
Egg-adaptive mutations in H3N2v vaccine virus enhance egg-based production without loss of antigenicity or immunogenicity.
Vaccine - 22 Jun 2015
Barman Subrata, Franks John, Turner Jasmine C, Yoon Sun-Woo, Webster Robert G, Webby Richard J
Abstract excerpt
The recently detected zoonotic H3N2 variant influenza A (H3N2v) viruses have caused 343 documented cases of human infection linked to contact with swine. An effective vaccine is needed for these viruses, which may acquire transmissibility among humans. However, viruses isolated from human cases do not replicate well in embryonated chicken eggs, posing an obstacle to egg-based vaccine production. To address this...
Topics
- Adaptation, Physiological
- Amino Acid Substitution
- Animals
- Antibodies, Viral
- Chick Embryo
- Ferrets
- Hemagglutinin Glycoproteins, Influenza Virus
- Humans
- Influenza A Virus, H1N1 Subtype
- Influenza A Virus, H3N2 Subtype
- Male
- Mutation
- Serial Passage