Article
Minimization of genetic distances by the consensus, ancestral, and center-of-tree (COT) sequences for HIV-1 variants within an infected individual and the design of reagents to test immune reactivity.
Virology - 10 May 2006
Kesturu Girish S, Colleton Bonnie A, Liu Yi, Heath Laura, Shaikh Obaid Shakil, Rinaldo Charles R, Shankarappa Raj
Abstract excerpt
Eliciting maximal immune responses to highly divergent viruses is a challenge and a focus in AIDS vaccine development. Another challenge is to identify the immune correlates of protective immunity. Recent AIDS vaccine design approaches attempt to use reconstructed centralized viral sequences that minimize genetic differences to circulating viruses. Using these approaches, we derive and analyze consensus (CON),...
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