Article
An evaluation of phylogenetic methods for reconstructing transmitted HIV variants using longitudinal clonal HIV sequence data.
Journal of virology - 1 Jun 2014
McCloskey Rosemary M, Liang Richard H, Harrigan P Richard, Brumme Zabrina L, Poon Art F Y
Abstract excerpt
UNLABELLED: A population of human immunodeficiency virus (HIV) within a host often descends from a single transmitted/founder virus. The high mutation rate of HIV, coupled with long delays between infection and diagnosis, make isolating and characterizing this strain a challenge. In theory, ancestral reconstruction could be used to recover this strain from sequences sampled in chronic infection; however, the...
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