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Article

Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity.

Expert review of vaccines - 1 Aug 2004

Gao Feng, Korber Bette T, Weaver Eric, Liao Hua-Xin, Hahn Beatrice H, Haynes Barton F

Abstract excerpt

Genetic variation of HIV-1 represents a major obstacle for AIDS vaccine development. With the amino acid sequence divergence as high as 30% in envelopes between different subtypes among HIV-1 group M viruses, it is unlikely that cross-subtype protection will occur equally well among all subtypes. Computer programs have been used to generate 'centralized' HIV gene sequences: consensus, ancestor or center of the...

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Identifiers

PMID: 15285714
DOI: 10.1586/14760584.3.4.s161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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