Article
Coping with viral diversity in HIV vaccine design.
PLoS computational biology - 27 Apr 2007
Nickle David C, Rolland Morgane, Jensen Mark A, Pond Sergei L Kosakovsky, Deng Wenjie, Seligman Mark, Heckerman David, Mullins James I, Jojic Nebojsa
Abstract excerpt
The ability of human immunodeficiency virus type 1 (HIV-1) to develop high levels of genetic diversity, and thereby acquire mutations to escape immune pressures, contributes to the difficulties in producing a vaccine. Possibly no single HIV-1 sequence can induce sufficiently broad immunity to protect against a wide variety of infectious strains, or block mutational escape pathways available to the virus after...
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