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Article

Sequence evolution of HIV-1 following mother-to-child transmission.

Journal of virology - 1 Dec 2010

Ryland Elizabeth G, Tang Yanhua, Christie Celia D, Feeney Margaret E

Abstract excerpt

The genetic heterogeneity of HIV-1 poses a major obstacle to vaccine development. Although most horizontally acquired HIV-1 infections are initiated by a single homogeneous virus, marked genetic diversification and evolution occur following transmission. The relative contribution of the antiviral immune response to intrahost viral evolution remains controversial, in part because the sequence of the transmitted...

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Identifiers

PMID: 20861265
DOI: 10.1128/JVI.01617-10
PMCID: PMC2976410

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Source receipt: pubmed, retrieved 7 Sept 2026.

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