Article
Reconstructing the dynamics of HIV evolution within hosts from serial deep sequence data.
PLoS computational biology - 1 Jan 2012
Poon Art F Y, Swenson Luke C, Bunnik Evelien M, Edo-Matas Diana, Schuitemaker Hanneke, van 't Wout Angélique B, Harrigan P Richard
Abstract excerpt
At the early stage of infection, human immunodeficiency virus (HIV)-1 predominantly uses the CCR5 coreceptor for host cell entry. The subsequent emergence of HIV variants that use the CXCR4 coreceptor in roughly half of all infections is associated with an accelerated decline of CD4+ T-cells and rate of progression to AIDS. The presence of a 'fitness valley' separating CCR5- and CXCR4-using genotypes is...
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