Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels.

mBio - 9 Jun 2020

Han Changze, Johnson Jacklyn, Dong Rentian, Kandula Raghavendranath, Kort Alexa, Wong Maria, Yang Tianbao, Breheny Patrick J, Brown Grant D, Haim Hillel

Abstract excerpt

HIV-1 group M was transmitted to humans nearly one century ago. The virus has since evolved to form distinct clades, which spread to different regions of the world. The envelope glycoproteins (Envs) of HIV-1 have rapidly diversified in all infected populations. We examined whether key antigenic sites of Env and signatures of vaccine efficacy are evolving toward similar or distinct structural forms in different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Vaccines
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Founder Effect

Share to Genetic Variation

Share to HIV Antibodies

Share to HIV Infections

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 32518179
DOI: 10.1128/mBio.00126-20
PMCID: PMC7373194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels.PMID 32518179Read ↗

Gradual decrease in the inter-population diversity of HIV-1 Env among group M lineages worldwideSemantic proximity Read ↗

Appreciating HIV type 1 diversity: subtype differences in Env.Semantic proximity Read ↗

Dissecting the dynamics of HIV-1 protein sequence diversity.Semantic proximity Read ↗

Impact of genetic diversity of HIV-1 on diagnosis, antiretroviral therapy & vaccine development.Semantic proximity Read ↗

Molecular variants of HIV-1 and their impact on vaccine development.Semantic proximity Read ↗

Evolutionary and immunological implications of contemporary HIV-1 variation.Semantic proximity Read ↗

HIV molecular epidemiology: transmission and adaptation to human populations.Semantic proximity Read ↗

Molecular epidemiology of HIV-1 variants in the global AIDS pandemic: an update.Semantic proximity Read ↗

Human immunodeficiency virus type 1 env evolves toward ancestral states upon transmission to a new host.Semantic proximity Read ↗

Distinct antibody-mediated selection in a narrow-source HIV-1 outbreak among Chinese former plasma donorsSemantic proximity Read ↗

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection.Semantic proximity Read ↗

The implications of patterns in HIV diversity for neutralizing antibody induction and susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.