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Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity.

AIDS (London, England) - 19 Feb 2008

Frahm Nicole, Nickle David C, Linde Caitlyn H, Cohen Daniel E, Zuñiga Rosario, Lucchetti Aldo, Roach Timothy, Walker Bruce D, Allen Todd M, Korber Bette T, Mullins James I, Brander Christian

Abstract excerpt

OBJECTIVE: To evaluate the recognition of computationally designed, centralized HIV-1 antigens derived from clade B, C and group M sequences by individuals infected with HIV-1-M clades B and C. METHODS: Three centralized sequences have been described - consensus, ancestor and center-of-tree - each of which attempts to minimize the genetic distance to circulating viruses. It is unclear whether any of these...

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PMID: 18301057
DOI: 10.1097/QAD.0b013e3282f42412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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