Article
alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.
Science (New York, N.Y.) - 17 Mar 2006
Lien Wen-Hui, Klezovitch Olga, Fernandez Tania E, Delrow Jeff, Vasioukhin Valeri
Abstract excerpt
During development, cells monitor and adjust their rates of accumulation to produce organs of predetermined size. We show here that central nervous system-specific deletion of the essential adherens junction gene, alphaE-catenin, causes abnormal activation of the hedgehog pathway, resulting in shortening of the cell cycle, decreased apoptosis, and cortical hyperplasia. We propose that alphaE-catenin connects...
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