Katanin p80 regulates human cortical development by limiting centriole and cilia number.

doi:10.1016/j.neuron.2014.12.017

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Article

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron - 17 Dec 2014

Hu Wen F, Pomp Oz, Ben-Omran Tawfeg, Kodani Andrew, Henke Katrin, Mochida Ganeshwaran H, Yu Timothy W, Woodworth Mollie B, Bonnard Carine, Raj Grace Selva, Tan Thong Teck, Hamamy Hanan, Masri Amira, Shboul Mohammad, Al Saffar Muna, Partlow Jennifer N, Al-Dosari Mohammed, Alazami Anas, Alowain Mohammed, Alkuraya Fowzan S, Reiter Jeremy F, Harris Matthew P, Reversade Bruno, Walsh Christopher A

Abstract excerpt

Katanin is a microtubule-severing complex whose catalytic activities are well characterized, but whose in vivo functions are incompletely understood. Human mutations in KATNB1, which encodes the noncatalytic regulatory p80 subunit of katanin, cause severe microlissencephaly. Loss of Katnb1 in mice confirms essential roles in neurogenesis and cell survival, while loss of zebrafish katnb1 reveals specific roles for...

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Identifiers

PMID: 25521379
DOI: 10.1016/j.neuron.2014.12.017
PMCID: PMC4485387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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