Article
beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system.
Developmental biology - 15 Jun 2003
Zechner Dietmar, Fujita Yasuyuki, Hülsken Jörg, Müller Thomas, Walther Ingrid, Taketo Makoto M, Crenshaw E Bryan, Birchmeier Walter, Birchmeier Carmen
Abstract excerpt
beta-Catenin is an essential component of the canonical Wnt signaling system that controls decisive steps in development. We employed here two conditional beta-catenin mutant alleles to alter beta-catenin signaling in the central nervous system of mice: one allele to ablate beta-catenin and the second allele to express a constitutively active beta-catenin. The tissue mass of the spinal cord and brain is reduced...
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