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Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated -Catenin Signaling

15 Jul 2015

Abstract excerpt

Abnormal patterns of head and brain growth are a replicated finding in a subset of individuals with autism spectrum disorder (ASD). It is not known whether risk factors associated with ASD and abnormal brain growth (both overgrowth and undergrowth) converge on common biological pathways and cellular mechanisms in the developing brain. Heterozygous mutations in PTEN (PTEN(+/-)), which encodes a negative regulator...

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PMID: 26180201
DOI: 10.1523/jneurosci.5272-14.2015

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