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Article

Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis.

Neural development - 4 Sept 2009

Jen Yi-Huei Linda, Musacchio Michele, Lander Arthur D

Abstract excerpt

BACKGROUND: Cell surface heparan sulfate proteoglycans (HSPGs) act as co-receptors for multiple families of growth factors that regulate animal cell proliferation, differentiation and patterning. Elimination of heparan sulfate during brain development is known to produce severe structural abnormalities. Here we investigate the developmental role played by one particular HSPG, glypican-1 (Gpc1), which is...

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Identifiers

PMID: 19732411
DOI: 10.1186/1749-8104-4-33
PMCID: PMC2746204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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