Article
Inactivation of 5HT transport in mice: modeling altered 5HT homeostasis implicated in emotional dysfunction, affective disorders, and somatic syndromes.
Handbook of experimental pharmacology - 1 Jan 2006
Lesch K P, Mössner R
Abstract excerpt
Animal models have not only become an essential tool for investigating the neurobiological function of genes that are involved in the etiopathogenesis of human behavioral and psychiatric disorders but are also fundamental in the development novel therapeutic strategies. As an example, inactivation of the serotonin (5HT) transporter (5Htt, Slc6a4) gene in mice expanded our view of adaptive 5HT uptake regulation...
Topics
- Affective Symptoms
- Animals
- Brain
- Depressive Disorder
- Environment
- Genetic Predisposition to Disease
- Homeostasis
- Hypertension, Pulmonary
- Irritable Bowel Syndrome
- Mice
- Mice, Knockout