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Article

Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses

6 Mar 2006

Abstract excerpt

We demonstrated previously that the cytosine deaminase APOBEC3G inhibits retrotransposition of two active murine endogenous retroviruses, namely intracisternal A-particles (IAP) and MusD, in an ex vivo assay where retrotransposition was monitored by selection of neo-marked elements. Sequencing of the transposed copies further disclosed extensive editing, resulting in a high load of G-to-A mutations. Here, we...

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PMID: 16537839
DOI: 10.1093/nar/gkl054

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