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Article

Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates.

eLife - 1 Jun 2020

Yang Lei, Emerman Michael, Malik Harmit S, McLaughlin Richard N

Abstract excerpt

Host-virus arms races are inherently asymmetric; viruses evolve much more rapidly than host genomes. Thus, there is high interest in discovering mechanisms by which host genomes keep pace with rapidly evolving viruses. One family of restriction factors, the APOBEC3 (A3) cytidine deaminases, has undergone positive selection and expansion via segmental gene duplication and recombination. Here, we show that new...

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Identifiers

PMID: 32479260
DOI: 10.7554/eLife.58436
PMCID: PMC7263822

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