Article
Astrocytes survive chronic infection and cytopathic effects of the ts1 mutant of the retrovirus Moloney murine leukemia virus by upregulation of antioxidant defenses.
Journal of virology - 1 Apr 2006
Qiang Wenan, Kuang Xianghong, Liu Jinrong, Liu Na, Scofield Virginia L, Reid Amy J, Jiang Yuhong, Stoica Gheorghe, Lynn William S, Wong Paul K Y
Abstract excerpt
The ts1 mutant of Moloney murine leukemia virus (MoMuLV) induces a neurodegenerative disease in mice, in which glial cells are infected by the retrovirus but neurons are not. ts1 infection of primary astrocytes, or of the immortalized astrocytic cell line C1, results in accumulation of the ts1 gPr80(env) envelope protein in the endoplasmic reticulum (ER), with ER and oxidative stress. Notably, only about half of...
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