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Article

Correlation of specific virus-astrocyte interactions and cytopathic effects induced by ts1, a neurovirulent mutant of Moloney murine leukemia virus.

Journal of virology - 1 Mar 1993

Shikova E, Lin Y C, Saha K, Brooks B R, Wong P K

Abstract excerpt

ts1 is a highly neuropathogenic and lymphocytopathic mutant of Moloney murine leukemia virus TB (MoMuLV-TB). We previously reported that the primary neuropathogenic determinant of ts1 maps to a single amino acid substitution, Val-25-->Ile, in precursor envelope protein gPr80env. This Val-25-->Ile substitution apparently renders gPr80env inefficient for transport from the endoplasmic reticulum to the Golgi...

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Identifiers

PMID: 8437206
DOI: 10.1128/JVI.67.3.1137-1147.1993
PMCID: PMC237478

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Source receipt: pubmed, retrieved 7 Sept 2026.

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