Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Correlation of specific virus-astrocyte interactions and cytopathic effects induced by ts1, a neurovirulent mutant of Moloney murine leukemia virus.

Journal of virology - 1 Mar 1993

Shikova E, Lin Y C, Saha K, Brooks B R, Wong P K

Abstract excerpt

ts1 is a highly neuropathogenic and lymphocytopathic mutant of Moloney murine leukemia virus TB (MoMuLV-TB). We previously reported that the primary neuropathogenic determinant of ts1 maps to a single amino acid substitution, Val-25-->Ile, in precursor envelope protein gPr80env. This Val-25-->Ile...

Topics

Animals
Astrocytes
Cell Compartmentation
Cells, Cultured
Cytopathogenic Effect, Viral
Diencephalon
Endoplasmic Reticulum
Endothelium, Vascular
Golgi Apparatus
Mice
Mice, Inbred Strains
Moloney murine leukemia virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Precursors

Protein Processing, Post-Translational

Viral Envelope Proteins

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 8437206
DOI: 10.1128/JVI.67.3.1137-1147.1993
PMCID: PMC237478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8437206-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Correlation of specific virus-astrocyte interactions and cytopathic effects induced by ts1, a neurovirulent mutant of Moloney murine leukemia virus.PMID 8437206Read ↗

Murine leukemia virus induced central nervous system diseases.Semantic proximity Read ↗

Astrocytes survive chronic infection and cytopathic effects of the ts1 mutant of the retrovirus Moloney murine leukemia virus by upregulation of antioxidant defenses.Semantic proximity Read ↗

Electron-microscopic immunocytochemical study of the intracellular transport of the viral glycoproteins in ts1, a mutant of Moloney murine leukemia virus.Semantic proximity Read ↗

Oligomerization and transport of the envelope protein of Moloney murine leukemia virus-TB and of ts1, a neurovirulent temperature-sensitive mutant of MoMuLV-TB.Semantic proximity Read ↗

A Val-25-to-Ile substitution in the envelope precursor polyprotein, gPr80env, is responsible for the temperature sensitivity, inefficient processing of gPr80env, and neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.Semantic proximity Read ↗

Differential effects of SARS-CoV-2 variants on central nervous system cells and blood–brain barrier functionsSemantic proximity Read ↗

Construction and characterization of expression systems for the env gene of ts1, a mutant of Moloney murine leukemia virus-TB.Semantic proximity Read ↗

TR1.3 viral pathogenesis and syncytium formation are linked to Env-Gag cooperation.Semantic proximity Read ↗

Interaction between endoplasmic reticulum stress and caspase 8 activation in retrovirus MoMuLV-ts1-infected astrocytes.Semantic proximity Read ↗

An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication of Human Immunodeficiency Virus Types 1 and 2 in Brain-Derived CellsSemantic proximity Read ↗

Murine retroviral-induced spongiform neuronal degeneration parallels resident microglial cell infection: ultrastructural findings.Semantic proximity Read ↗

Bovine brain microvascular endothelial cells transfected with SV40-large T antigen: Development of an immortalized cell line to study pathophysiology of CNS diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.