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Article

Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain.

Aging cell - 1 Feb 2017

Ishii Takamasa, Takanashi Yumi, Sugita Koichi, Miyazawa Masaki, Yanagihara Rintaro, Yasuda Kayo, Onouchi Hiromi, Kawabe Noboru, Nakata Munehiro, Yamamoto Yorihiro, Hartman Phil S, Ishii Naoaki

Abstract excerpt

The etiology of astrocyte dysfunction is not well understood even though neuronal defects have been extensively studied in a variety of neuronal degenerative diseases. Astrocyte defects could be triggered by the oxidative stress that occurs during physiological aging. Here, we provide evidence that intracellular or mitochondrial reactive oxygen species (ROS) at physiological levels can cause hippocampal...

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Identifiers

PMID: 27623715
DOI: 10.1111/acel.12523
PMCID: PMC5242301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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