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Article

Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy.

Nature communications - 4 Jan 2018

Ignatenko Olesia, Chilov Dmitri, Paetau Ilse, de Miguel Elena, Jackson Christopher B, Capin Gabrielle, Paetau Anders, Terzioglu Mugen, Euro Liliya, Suomalainen Anu

Abstract excerpt

Mitochondrial dysfunction manifests as different neurological diseases, but the mechanisms underlying the clinical variability remain poorly understood. To clarify whether different brain cells have differential sensitivity to mitochondrial dysfunction, we induced mitochondrial DNA (mtDNA) depletion in either neurons or astrocytes of mice, by inactivating Twinkle (TwKO), the replicative mtDNA helicase. Here we...

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Identifiers

PMID: 29302033
DOI: 10.1038/s41467-017-01859-9
PMCID: PMC5754366

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