Article
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2006
Tam Issan Yee San, Chung Lap Ping, Suen Wai Sing, Wang Elaine, Wong May C M, Ho Kok Keung, Lam Wah Kit, Chiu Shui Wah, Girard Luc, Minna John D, Gazdar Adi F, Wong Maria P
Abstract excerpt
PURPOSE: This study evaluated the mutational profile of epidermal growth factor receptor (EGFR) and KRAS in non-small cell lung cancers in Hong Kong and determined their relation with smoking history and other clinicopathologic features. EXPERIMENTAL DESIGN: Mutational profile of exons 18 to 21 of EGFR and codons 12, 13, and 61 of KRAS were determined in 215 adenocarcinomas, 15 squamous cell (SCC), and 11...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.