Article
Clinicopathologic characteristics of the EGFR gene mutation in non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2006
Tsao Anne S, Tang Xi Ming, Sabloff Bradley, Xiao Lianchun, Shigematsu Hisayuki, Roth Jack, Spitz Margaret, Hong Waun Ki, Gazdar Adi, Wistuba Ignacio
Abstract excerpt
BACKGROUND: The authors sought to define clinicopathologic features associated with mutations of the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer (NSCLC). METHODS: The authors evaluated surgically resected NSCLC tumors for EGFR (exons 18-21) and KRAS (codons 12-13) mutations and immunohistochemistry (EGFR, phosphorylated-EGFR, and HER2/Neu), and correlated results with clinical...
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