Article
Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers.
PloS one - 1 Jan 2011
Li Chenguang, Fang Rong, Sun Yihua, Han Xiangkun, Li Fei, Gao Bin, Iafrate A John, Liu Xin-Yuan, Pao William, Chen Haiquan, Ji Hongbin
Abstract excerpt
PURPOSE: We previously showed that 90% (47 of 52; 95% CI, 0.79 to 0.96) of lung adenocarcinomas from East Asian never-smokers harbored well-known oncogenic mutations in just four genes: EGFR, HER2, ALK, and KRAS. Here, we sought to extend these findings to more samples and identify driver alterations in tumors negative for these mutations. EXPERIMENTAL DESIGN: We have collected and analyzed 202 resected lung...
Topics
- Adenocarcinoma
- Adenocarcinoma of Lung
- Asian People
- Base Sequence
- DNA Mutational Analysis
- ErbB Receptors
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Neoplasm
- Genetic Predisposition to Disease