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Article

Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers.

PloS one - 1 Jan 2011

Li Chenguang, Fang Rong, Sun Yihua, Han Xiangkun, Li Fei, Gao Bin, Iafrate A John, Liu Xin-Yuan, Pao William, Chen Haiquan, Ji Hongbin

Abstract excerpt

PURPOSE: We previously showed that 90% (47 of 52; 95% CI, 0.79 to 0.96) of lung adenocarcinomas from East Asian never-smokers harbored well-known oncogenic mutations in just four genes: EGFR, HER2, ALK, and KRAS. Here, we sought to extend these findings to more samples and identify driver alterations in tumors negative for these mutations. EXPERIMENTAL DESIGN: We have collected and analyzed 202 resected lung...

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Identifiers

PMID: 22140546
DOI: 10.1371/journal.pone.0028204
PMCID: PMC3227646

Genes

EGFR
ALK
KRAS
BRAF
ROS1
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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