Article
Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma.
British journal of cancer - 8 Aug 2005
Sonobe M, Manabe T, Wada H, Tanaka F
Abstract excerpt
Epidermal growth factor receptor (EGFR) mutations are a potential predictor of the effectiveness of EGFR inhibitors for the treatment of lung cancer. Although EGFR mutations were reported to occur with high frequency in nonsmoking Japanese adenocarcinoma patients, the exact nature has not been fully elucidated. We examined EGFR gene mutations within exons 18-21 and their correlations to clinico-pathological...
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