Frequency of well-identified oncogenic driver mutations in lung adenocarcinoma of smokers varies with histological subtypes and graduated smoking dose.

doi:10.1016/j.lungcan.2012.09.018

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Article

Frequency of well-identified oncogenic driver mutations in lung adenocarcinoma of smokers varies with histological subtypes and graduated smoking dose.

Lung cancer (Amsterdam, Netherlands) - 1 Jan 2013

Li Hang, Pan Yunjian, Li Yuan, Li Chenguang, Wang Rui, Hu Haichuan, Zhang Yang, Ye Ting, Wang Lei, Shen Lei, Sun Yihua, Chen Haiquan

Abstract excerpt

PURPOSE: We performed this analysis to reveal the association between six well-identified oncogenic driver mutations and clinical and pathological features in lung adenocarcinomas from smokers. It may have the potentiality to optimize existing treatment strategies and clinical trial design. METHO...

Topics

Adenocarcinoma
Adult
Aged
China
Class I Phosphatidylinositol 3-Kinases
DNA Mutational Analysis
ErbB Receptors
Humans
Lung Neoplasms
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

Oncogene Proteins, Fusion

Oncogenes

Phosphatidylinositol 3-Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed

Identifiers

PMID: 23098378
DOI: 10.1016/j.lungcan.2012.09.018

Genes

EGFR
KRAS
ALK
BRAF
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-23098378-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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