Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.

Journal of the National Cancer Institute - 2 Mar 2005

Shigematsu Hisayuki, Lin Li, Takahashi Takao, Nomura Masaharu, Suzuki Makoto, Wistuba Ignacio I, Fong Kwun M, Lee Huei, Toyooka Shinichi, Shimizu Nobuyoshi, Fujisawa Takehiko, Feng Ziding, Roth Jack A, Herz Joachim, Minna John D, Gazdar Adi F

Abstract excerpt

BACKGROUND: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that inhibit EGFR kinase activity. However, the role of such mutations in the pathogenesis of lung cancers is unclear. METHODS: We sequenced exons 18-21 of the EGFR TK domain from genomic DNA isolated from 617...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Australia
Share to Carcinoma, Neuroendocrine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Genes, erbB-1

Share to Genes, ras

Share to Papillomaviridae

Share to Protein-Tyrosine Kinases

Share to Taiwan

Source

Identifiers

PMID: 15741570
DOI: 10.1093/jnci/dji055

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.PMID 15741570Read ↗

Epidermal growth factor receptor mutations in lung cancers.Semantic proximity Read ↗

Clinicopathologic significance of the mutations of the epidermal growth factor receptor gene in patients with non-small cell lung cancer.Semantic proximity Read ↗

Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications.Semantic proximity Read ↗

Clinicopathologic characteristics of the EGFR gene mutation in non-small cell lung cancer.Semantic proximity Read ↗

Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smokingSemantic proximity Read ↗

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.Semantic proximity Read ↗

Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.Semantic proximity Read ↗

Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.Semantic proximity Read ↗

Relationship between epidermal growth factor receptor gene mutations and clinicopathological features in patients with non-small cell lung cancer in western Turkey.Semantic proximity Read ↗

Impact of smoking status and pathologic type on epidermal growth factor receptor mutations in lung cancer.Semantic proximity Read ↗

EGFR, ALK, RET, KRAS and BRAF alterations in never-smokers with non-small cell lung cancerSemantic proximity Read ↗

Tyrosine kinase inhibitors for epidermal growth factor receptor gene mutation-positive non-small cell lung cancers: an update for recent advances in therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.