Article
Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2012
Dogan Snjezana, Shen Ronglai, Ang Daphne C, Johnson Melissa L, D'Angelo Sandra P, Paik Paul K, Brzostowski Edyta B, Riely Gregory J, Kris Mark G, Zakowski Maureen F, Ladanyi Marc
Abstract excerpt
PURPOSE: The molecular epidemiology of most EGFR and KRAS mutations in lung cancer remains unclear. EXPERIMENTAL DESIGN: We genotyped 3,026 lung adenocarcinomas for the major EGFR (exon 19 deletions and L858R) and KRAS (G12, G13) mutations and examined correlations with demographic, clinical, and smoking history data. RESULTS: EGFR mutations were found in 43% of never smokers and in 11% of smokers. KRAS mutations...
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