Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement.

doi:10.1002/cncr.26311

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Article

Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement.

Cancer - 1 Feb 2012

Kim Hye Ryun, Shim Hyo Sup, Chung Jin-Haeng, Lee Young Joo, Hong Yun Kyoung, Rha Sun Young, Kim Se Hoon, Ha Sang-Jun, Kim Se Kyu, Chung Kyung Young, Soo Ross, Kim Joo Hang, Cho Byoung Chul

Abstract excerpt

BACKGROUND: The objectives of this study were to determine the proportions of major oncogenic alterations and to examine survival in genotype-specific subsets of never-smokers with nonsmall cell lung cancer (NSCLC). METHODS: The authors concurrently analyzed mutations in the epidermal growth factor receptor (EGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) genes and investigated anaplastic...

Topics

Adenocarcinoma
Adult
Aged
Anaplastic Lymphoma Kinase
Carcinoma, Large Cell
Carcinoma, Non-Small-Cell Lung
Carcinoma, Squamous Cell
ErbB Receptors
Female
Gene Rearrangement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lung Neoplasms

Male

Middle Aged

Mutation

Neoplasm Staging

Prognosis

Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 21720997
DOI: 10.1002/cncr.26311

Genes

EGFR
ALK
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21720997-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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