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Article

TMAO promotes fibrillization and microtubule assembly activity in the C-terminal repeat region of tau.

Biochemistry - 21 Mar 2006

Scaramozzino Francesca, Peterson Dylan W, Farmer Patrick, Gerig J T, Graves Donald J, Lew John

Abstract excerpt

Alzheimer's disease most closely correlates with the appearance of the neurofibrillary tangles (NFTs), intracellular fibrous aggregates of the microtubule-associated protein, tau. Under native conditions, tau is an unstructured protein, and its physical characterization has revealed no clues about the three-dimensional structural determinants essential for aggregation or microtubule binding. We have found that...

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Identifiers

PMID: 16533051
DOI: 10.1021/bi052167g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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