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Article

Trimethylamine N-oxide alleviates the severe aggregation and ER stress caused by G98R alphaA-crystallin.

Molecular vision - 19 Dec 2009

Gong Bo, Zhang Li-Yun, Pang Chi-Pui, Lam Dennis Shun-Chiu, Yam Gary Hin-Fai

Abstract excerpt

PURPOSE: Crystallins are major functional and structural proteins in mammalian lens. Their expression, distribution, and protein-protein interaction affect lens development and fiber cell differentiation. Mutated crystallins lead to structural and functional changes of lens structure and could lead to opacity formation and cataract development. The purpose of this study was to investigate the biological effects...

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Source

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Identifiers

PMID: 20029648
PMCID: PMC2796635

Genes

CRYAA
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Trimethylamine N-oxide alleviates the severe aggregation and ER stress caused by G98R alphaA-crystallin.PMID 20029648Read ↗

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