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Article

Initiation of assembly of tau(273-284) and its ΔK280 mutant: an experimental and computational study

1 Jan 2013

Abstract excerpt

The microtubule associated protein tau is essential for the development and maintenance of the nervous system. Tau dysfunction is associated with a class of diseases called tauopathies, in which tau is found in an aggregated form. This paper focuses on a small aggregating fragment of tau, (273)GKVQIINKKLDL(284), encompassing the (PHF6*) region that plays a central role in tau aggregation. Using a combination of...

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PMID: 23515417
DOI: 10.1039/c3cp00063j

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