Article
Natural osmolytes remodel the aggregation pathway of mutant huntingtin exon 1.
Biochemistry - 29 Mar 2011
Borwankar Tejas, Röthlein Christoph, Zhang Gong, Techen Anne, Dosche Carsten, Ignatova Zoya
Abstract excerpt
In response to stress small organic compounds termed osmolytes are ubiquitously accumulated in all cell types to regulate the intracellular solvent quality and to counteract the deleterious effect on the stability and function of cellular proteins. Given the evidence that destabilization of the native state of a protein either by mutation or by environmental changes triggers the aggregation in the...
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