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Article

Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO).

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2014

Ma Jianqiang, Pazos Ileana M, Gai Feng

Abstract excerpt

Although it is widely known that trimethylamine N-oxide (TMAO), an osmolyte used by nature, stabilizes the folded state of proteins, the underlying mechanism of action is not entirely understood. To gain further insight into this important biological phenomenon, we use the C≡N stretching vibration of an unnatural amino acid, p-cyano-phenylalanine, to directly probe how TMAO affects the hydration and...

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Identifiers

PMID: 24912147
DOI: 10.1073/pnas.1403224111
PMCID: PMC4060645

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