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Article

Genetic association analyses and meta-analysis of Dynorphin-Kappa Opioid system potential functional variants with heroin dependence.

Neuroscience letters - 15 Oct 2018

Yuanyuan Ji, Rui Su, Hua Tang, Jingjing Cui, Cuola Deji, Yuhui Shi, Shuguang Wei

Abstract excerpt

Prodynorphin (PDYN) binds to k-opioid receptors (KOPr; encoded by OPRK1) and is known to regulate dopaminergic tone, making this system important for drugs addiction. Dynorphin (Dyn)/KORr system are powerful effectors of stress-induced alterations in reward processing and dysphoric states. Thus, We identified 11 potential functional SNPs and one variable number of tandem repeat (VNTR) in this system, performed a...

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Source

Identifiers

PMID: 30138645
DOI: 10.1016/j.neulet.2018.08.023

Genes

PDYN
OPRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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