Article
Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features.
Blood - 1 Jul 2006
Rutella Sergio, Bonanno Giuseppina, Procoli Annabella, Mariotti Andrea, de Ritis Daniela G, Curti Antonio, Danese Silvio, Pessina Gloria, Pandolfi Simona, Natoni Federica, Di Febo Annalaura, Scambia Giovanni, Manfredini Rossella, Salati Simona, Ferrari Sergio, Pierelli Luca, Leone Giuseppe, Lemoli Roberto M
Abstract excerpt
Several hematopoietic growth factors, including interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1), promote the differentiation of tolerogenic dendritic cells (DCs). Hepatocyte growth factor (HGF) is a pleiotropic cytokine whose effects on human DC differentiation and function have not been investigated. Monocytes cultured with HGF (HGFMo) differentiated into accessory cells with DC-like...
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