Article
IL-34 induces the differentiation of human monocytes into immunosuppressive macrophages. antagonistic effects of GM-CSF and IFNγ.
PloS one - 1 Jan 2013
Foucher Etienne D, Blanchard Simon, Preisser Laurence, Garo Erwan, Ifrah Norbert, Guardiola Philippe, Delneste Yves, Jeannin Pascale
Abstract excerpt
IL-34 is a recently identified cytokine that signals via the M-CSF receptor and promotes monocyte survival. Depending on the environment, monocytes can differentiate into macrophages (Mφ) or dendritic cells (DC). A wide spectrum of Mφ and DC subsets, with distinct phenotypes and functions, has been described. To date, the phenotype of monocytes exposed to IL-34 remains unexplored. We report here that IL-34...
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