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Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells #

18 Feb 2009

Abstract excerpt

UNLABELLED: Interface hepatitis, the histological lesion typical of autoimmune hepatitis (AIH), is composed of CD4 and CD8 T lymphocytes and of innate immunity cells, particularly monocytes. Studies in AIH have focused on autoreactive CD4 and CD8 T cells and impairment of CD4+CD25+ regulatory T cells (T-regs), whereas little is known about the role of monocytes and their relationship with T-regs. We have...

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PMID: 19437492
DOI: 10.1002/hep.22914

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