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Article

Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation.

Immunology - 1 May 2010

Arimoto-Miyamoto Kazue, Kadowaki Norimitsu, Kitawaki Toshio, Iwata Satoshi, Morimoto Chikao, Uchiyama Takashi

Abstract excerpt

Studies in mice have shown that CD70 on dendritic cells (DCs) is sufficient to convert T-cell tolerance into immunity and hence induce anti-tumour immune responses. Therefore, it is important to investigate (i) optimal stimuli to induce CD70 on human monocyte-derived DCs (MoDCs), which are widely used for tumour immunotherapy, and (ii) the role of CD70 in functional differentiation of naive CD4(+) and CD8(+) T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20201989
DOI: 10.1111/j.1365-2567.2010.03220.x
PMCID: PMC2855801

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