Article
[In vitro selection and phenotyping of HIV-1 mutants resistant to azidothymidine and didanosine].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Jan 2005
Kiseleva Ia Iu, Pliasunova O A, Pokrovskaia N V, Pokrovskiĭ A G
Abstract excerpt
In vitro selection of HIV-1(EVK) variants resistant to highly effective nucleoside reverse transcriptase inhibitors (NNRTIs), i.e. azidothymidine (AZT) and didanosine (ddI) was performed. In case of AZT resistant mutants, subcloning by limiting dilutions was used. The isolated AZT resistant mutants and subclones had a broad spectrum of phenotypic resistance (8, 25, 53, 80, 114, 160-fold). The ddI resistant mutant...
Topics
- Didanosine
- Drug Resistance, Viral
- HIV-1
- Mutation
- Reverse Transcriptase Inhibitors
- Stavudine
- Thymidine
- Zidovudine