Article
In vitro selection of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine.
Antiviral research - 1 May 1992
Dianzani F, Antonelli G, Turriziani O, Dong G, Capobianchi M R, Riva E
Abstract excerpt
3'-Azido-3'-deoxythymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) was obtained by growing HTLV-IIIB in C8166 cell cultures in the presence of inhibitory concentrations of AZT. The AZT-resistant HIV-1 was capable of replicating, as measured by infectious virus yield, and induc...
Topics
- Antiviral Agents
- Cell Line
- Cytopathogenic Effect, Viral
- DNA, Viral
- Dideoxynucleotides
- Drug Resistance, Microbial
- Genetic Variation
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Mutation
- Polymerase Chain Reaction
- Reverse Transcriptase Inhibitors
- Selection, Genetic
- Thymine Nucleotides
- Virus Replication
- Zidovudine