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Article

Antiviral activity and resistance profile of phosphazid--a novel prodrug of AZT.

Nucleosides & nucleotides - 1 Jan 2000

Machado J, Salomon H, Oliveira M, Tsoukas C, Krayevsky A A, Wainberg M A

Abstract excerpt

Both AZT and its novel 5'-hydrogen phosphonate derivative, Phosphazid, possess similar in vitro activity and resistance profiles. Experiments involving AZT-resistant virus isolates revealed a strong correlation between resistance to AZT and cross-resistance to Phosphazid. In vitro selection for resistance to Phosphazid yielded viruses that were about 15-fold less sensitive than wild-type virus to this drug....

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PMID: 10432707
DOI: 10.1080/15257779908041597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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