Article
[Replicative properties of HIV-1 strains, resistant to 3'-azido-2'3'-dideoxythymidine].
Voprosy virusologii - 1 Jan 2000
Selimova L M, Iurin O G, Pokrovskiĭ V V
Abstract excerpt
The replicative activity of two strains of human immunodeficiency virus type I, 1974 and 1978, resistant to 3'-azido-2',3'-dideoxythymidine (AZT), was investigated. Assessment of AZT sensitivity by the standard method showed the 50% effective dose (ED50) for strain 1974 to be 0.1 mumole and for strain 1978, 1 mumole. Both strains had the slow/low. 3 phenotype. The level of virus-specific antigens in these strains...
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