Article
[Molecular basis and clinical significance of HIV-1 resistance to nucleoside compounds].
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Mar 1995
Wainberg M A, Gu Z, Salomon H, Arts E J, Kleiman L, Parniak M A, Morin N
Abstract excerpt
The prolonged use of anti-viral nucleosides (ZDV, ddI, ddC) in HIV-infected patients has given rise to the isolation of viral variants that display resistance against these compounds. Tissue culture selection experiments, involving increasing concentrations of anti-viral compounds, have likewise been shown to select for drug-resistant strains of HIV. Cloning, sequencing and site-directed mutagenesis have shown...
Topics
- Acquired Immunodeficiency Syndrome
- Drug Resistance, Multiple
- Genotype
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Mutation
- Nucleosides
- RNA-Directed DNA Polymerase