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Article

Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype.

Nucleosides & nucleotides - 1 Jan 2000

Gröschel B, Meier C, Zehner R, Cinatl J, Doerr H W, Cinatl J

Abstract excerpt

Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9rAZT250). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9rAZT250 cells, which exert decreased thymidine kinase (TK) gene expression.

Topics

Anti-HIV Agents
Base Sequence
Cell Line
DNA Primers
Drug Resistance, Microbial
HIV-1
Humans
Microbial Sensitivity Tests
Phenotype
Reverse Transcriptase Inhibitors
Reverse Transcriptase Polymerase Chain Reaction
Stavudine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thymidine Kinase

Zidovudine

Source

Identifiers

PMID: 10432712
DOI: 10.1080/15257779908041602

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