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Article

Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination Therapy

4 Aug 1995

Abstract excerpt

Combinations of antiretroviral drugs that prevent or delay the appearance of drug-resistant human immunodeficiency virus-type 1 (HIV-1) mutants are urgently required. Mutants resistant to 3'-azidothymidine (AZT, zidovudine) became phenotypically sensitive in vitro by mutation of residue 184 of viral reverse transcriptase to valine, which also induced resistance to (-)2'-deoxy-3'-thiacytidine (3TC). Furthermore,...

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Identifiers

PMID: 7542804
DOI: 10.1126/science.7542804

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Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination TherapyPMID 7542804Read ↗

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Combination 3TC/AZT therapy shows promise.Semantic proximity Read ↗

Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro.Semantic proximity Read ↗

Development and significance of nucleoside drug resistance in infection caused by the human immunodeficiency virus type 1.Semantic proximity Read ↗

3'-Azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1.Semantic proximity Read ↗

Viral resistance and the selection of antiretroviral combinations.Semantic proximity Read ↗

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Emergence of mutant HIV reverse transcriptase conferring resistance to AZT.Semantic proximity Read ↗

Evolution of AZT resistance in HIV-1: the 41-70 intermediate that is not observed in vivo has a replication defect.Semantic proximity Read ↗

Combination of drugs and drug-resistant reverse transcriptase results in a multiplicative increase of human immunodeficiency virus type 1 mutant frequencies.Semantic proximity Read ↗

3'-Azido-3'-deoxythymidine (AZT) mediates cross-resistance to nucleoside analogs in the case of AZT-resistant human immunodeficiency virus type 1 variants.Semantic proximity Read ↗

A Novel Polymorphism at Codon 333 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Can Facilitate Dual Resistance to Zidovudine and l -2′,3′-Dideoxy-3′-ThiacytidineSemantic proximity Read ↗

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