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Differences in Predicted Warfarin Dosing Requirements Between Hmong and East Asians Using Genotype-Based Dosing Algorithms.

Pharmacotherapy - 1 Mar 2021

Sun Boguang, Wen Ya-Feng, Culhane-Pera Kathleen A, Lo Muaj, Xiong Txia, Lee Koobmeej, Peng Kerui, Thyagarajan Bharat, Bishop Jeffrey R, Zierhut Heather, Straka Robert J

Abstract excerpt

INTRODUCTION: Warfarin's narrow therapeutic index and high variability in dosage requirements make dosage selection critical. Genetic factors are known to impact warfarin dosage selection. The Hmong are a unique Asian subpopulation numbering over 278,000 in the United States whose participation in genetics-based research is virtually nonexistent. The translational significance of early reports of warfarin...

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PMID: 33202062
DOI: 10.1002/phar.2487

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