Article
Numb Suppresses Notch-Dependent Activation of Enhancer of split during Lateral Inhibition in the Drosophila Embryonic Nervous System.
Biomolecules - 26 Aug 2024
Mujizah Elzava Yuslimatin, Kuwana Satoshi, Matsumoto Kenjiroo, Gushiken Takuma, Aoyama Naoki, Ishikawa Hiroyuki O, Sasamura Takeshi, Umetsu Daiki, Inaki Mikiko, Yamakawa Tomoko, Baron Martin, Matsuno Kenji
Abstract excerpt
The role of Drosophila numb in regulating Notch signaling and neurogenesis has been extensively studied, with a particular focus on its effects on the peripheral nervous system (PNS). Previous studies based on a single loss-of-function allele of numb, numb1, showed an antineurogenic effect on the peripheral nervous system (PNS), which revealed that the wild-type numb suppresses Notch signaling. In the current...
Topics
- Animals
- Drosophila Proteins
- Receptors, Notch
- Signal Transduction
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Neurogenesis
- Phenotype
- Nerve Tissue Proteins
- Alleles
- Mutation
- Nervous System