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Clinicopathological significance of mitochondrial D-Loop mutations in head and neck carcinoma

21 Feb 2006

Abstract excerpt

Mitochondrial DNA mutations have been reported in several types of tumours, including head and neck squamous cell carcinoma (HNSCC). The noncoding region of the Displacement-Loop (D-Loop) has emerged as a mutational hotspot and we recently found that they were associated with prognosis and response to 5 fluorouracil (5FU) in colon cancers. In order to evaluate the frequence of D-Loop mutations in a large series...

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PMID: 16495928
DOI: 10.1038/sj.bjc.6602993

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